For decades, a small number of foundations put their mission and grant-giving priorities on the table simultaneously with their investment portfolio as they sought ways to “invest with integrity” or have their investments help to advance their grantmaking priorities. No one formula or “secret sauce” allows a foundation to exercise its mission-related investment (MRI) commitment. Rather, the foundation and its board must determine its best route. Also, motivations vary for different foundations: acting with integrity; advancing grant-giving priorities; acting as a prudent fiduciary. This article cites examples of ways in which foundations can translate their desire to be a mission-related investor into reality.